I am considering using Memantine (at 10mg/day) during a simultaneous Nicotine and Opioid withdrawal. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. It made me really dizzy, which I had already been struggling with after a concussion, and it made me feel drunk. Learn more about Medicare prescription drug plans and savings with GoodRx. Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. I am now at 15 mg for the last few weeks to see if I can get any further improvement. I was able to have my mom back for two years until stroke. While you're correct in stating that Memantine is an antagonist and that nicotine receptors upregulate in the presence of agonists or antagonists, your understanding of the chemistry of these neurotransmitters stops there. I'm sorry we gave these to my dad.”, Namenda (memantine) for Alzheimer's Disease: “It was a wonderful drug for my mother, with dementia, at 77. If your dose is different, do not change it unless your doctor tells you to do so. When you first start taking this medication, you will usually take it once daily. Being able to understand nonverbal communication and verbal communication is huge improvements. Namenda XR. Not sure how long this will last.”, For Alzheimer's Disease: “My mother has Dementia. The extended release is better for the Alzheimer's patients. He has had Parkinsons about 10 years. It is less preferred than acetylcholinesterase inhibitors such as donepezil. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Memantine is a prescription drug used to treat moderate to severe confusion (dementia) related to Alzheimer's disease. Memantine is a prescription drug. Diarrhea 5. I don't abuse my friends and family, my anxiety is significantly lessened, and I can act normally in social situations. The dosage is based on your medical condition and response to treatment. Namenda, I don't know how long this will last, but I see a marked improvement.”. It stops the intrusive thoughts, rumination, and repetitive thinking which is a Godsend. It did not rectify some of the mental losses, but she no longer experienced hallucinations (in jail; on a boat). It has changed my life for the better. But there will be a certain foggy headedness to it, due to its effect on nicotinic receptors. This help me with anxiety. The extended-release is available in 28mg, 21mg, 14mg, and 7mg. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners. Its very expensive and difficult to give. I have researched the side affects and confusion is one of them. These mind altering drugs are BAD! The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. The Luvox is a different story. Mum has become very sleepy again so not sure if it’s the dementia or meds. check it out. If the pump does not function as described during intended use and according to instruction, the patient should consult the treating physician or a pharmacist. Last week her doctor said disease progressing too fast so put her on Memantine. In the middle she missed her pill for 1 week and her condition became worse like hallucinations, forgetting family members and not dressing properly. I always use Nicotine with my Opioids, and never just take one or the other. Patient forgets recent events and the doctor told us it was due to insufficient blood supply to the brain. MEMANTINE is used to treat dementia caused by Alzheimer's disease. My brother also has been giving our dad dioralyte for dehydration and movicol to help his bowel movements and a combination of all these seem to have greatly improved dads whole well being.”, For Migraine: “Very happy with this drug! The memantine has been remarkable for his memory and parkinsons and how it has brought him back around, I am amazed at what all he remembers and just occasionally has a little problem. So in a way it will only help you out. It also helps with my obsessive and aggressive problems! Dizzy 6. Press J to jump to the feed. I have gone from having ~12 headaches a month to around 4 mild ones very quickly. I think that this drug may help in the earlier stages. No special requirements. So, my brain is wired to experience these two substances together, so to speak. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Less meltdowns. Not all pack sizes may be marketed. During this time she regressed mentally. It came at the end of the year when insurance wouldn't pay for the drug. This is a generic drug. Broken shoulder then a broken wrist. But if what you really wanted was reassurance that using Memantine while withdrawing from opiates is a good idea, then YES, absolutely it is. He has been on the medication for about 6 weeks and I see a huge improvement. She was extremely agitated, angry and weepy. She's been taking Donepezil (Aricept) for about 5 years. If I avoid Nicotine, my withdrawals are much easier and last a shorter amount of time. Due to the long half-life of Memantine, it could mean several more days of misery for me if my experiment doesn't pan out. It also reduces repetitive behaviour/stereotypes. I hope this works on her for long long time.”, For Alzheimer's Disease: “Problem. 10mg x2 a day as separate doses =20mg Namenda is available in 5mg and 10mg capsules and as an oral solution of a strength equivalent to 2 mg of Memantine HCL in each ml. The memantine dosage will differ based on the use case. Side Effects. ... help Reddit App Reddit coins Reddit premium Reddit … Week 4/Maintenance Dose: 20 mg orally/day (Administer 10 mg twice a day.) Not too many side effects to date. Sorry so many people have not been helped as he has but I can say Thank God it works great for him so far.”, Namenda (memantine) for Alzheimer's Disease: “My mother has taken aricept for 5 years. My brain felt slow, my whole body felt heavy, and walking was really hard because of the dizziness. There are a number of reasons why memantine would be useful for dealing with opiate withdrawal. The doctor had him on so many meds, this being one along with Zoloft. The following information includes only the average doses of this medicine. I tell everyone. The patient had consumed Memantine in conjunction with unspecified anti-diabetic medications. I have no side effects that are apparent to me- a little burning in my legs for a few days when I increase the dose.”, For Alzheimer's Disease: “My dad was in advanced stage Alzheimer's, experiencing hallucinations and garbled sentence. So I waited for two weeks without drug to resume insurance at the first of the year. Not a full fix for me but huge help. And prescribed Dement (memantine). He is back over in his garden pottering about, he remembers all our names knows who he is again laughs tell jokes and has his little sarcastic humor back! I haven't noticed any side effects, maybe a little brain fog, but that has disappeared with continued use.”, For Alzheimer's Disease: “Started this about 5 weeks ago and take 10mg 2x daily. After 2 weeks, I've had to cut my adderall dose almost in half (from 25mg to 15mg) because 25mg is WAY too strong now. As with any drug, it may not work for others, but it was truly a God-send for my sweet mother. Week 3: 15 mg orally/day (Administer 5 mg and 10 mg as separate doses.) Memantine is a nicotinic antagonist, which from my limited understanding, both nicotinic Agonists (such as Nicotine) and nicotinic Antagonists (such as Memantine) both upregulate nicotinic receptors. NAMENDA (memantine hydrochloride) is indicated for the treatment of moderate to severe dementia of the Alzheimer’s type. Brand Names: Namenda, Namenda Titration Pak. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. She was withdrawing into herself and had little awareness of her surroundings and had difficulty with dressing and toileting. Both the research [18] and anecdotal reports [19] recount as much. I am considering using Memantine (at 10mg/day) during a simultaneous Nicotine and Opioid withdrawal. It became a miracle. EXTENDED-RELEASE: Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. I'm 62 and thankful for this medication.”, Namenda (memantine) for Alzheimer's Disease: “Mother-in-law has Alzheimer’s and it was severe to where she went into a memory care. She was able to get up her her self dressed like she had did prior to the alzheimers. Memantine is great. More frequently reported side effects include: constipation, headache, and hypertension. Does it have any effects on the nicotinic receptors? Took 2.5mg to start off low today too see if it'll help. Asking the doctor 'what other drug may work'? Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Take care and go up slowly on the memantine. Nothing short of a miracle. Also known as: Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Memantine, 3-MEO-PCE, LSD, 4-AcO-MiPT, 4-HO-MET, 2C-C, Clonazepam & Aripiprazole: Adventures in NMDA Receptor Antagonism: viscosity: Memantine & DXM: Just the Kick in the Teeth I Was Looking For: 180OnTheDVP: Memantine & Nitrous Oxide: Beyond Tollerance Reduction: Clyde T. The med is fully working yet please give it another chance and more time. Available for Android and iOS devices. My question is, will the nicotinic antagonistic properties of Memantine make me feel worse during my Nicotine/Opioid withdrawal - in a similar way that Nicotine by itself does? As of tomorrow it will be taken off”, For Alzheimer's Disease: “My mum was put on memantine just over a year ago for symptoms from vascular dementia. 6.6 Special precautions for disposal and other handling. She had to go to the ER due to a subconjunctival hemorrage which was very scary! Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. Seems to help my short term memory. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. Went back to the neurological doctor and explained every thing to him. Give it at least 2 weeks same time daily. Helps me slow down my mind to pay attention more and can respond to changes and sensory problems. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), … I would also recommend NAC to inhibit overall glutamate overactivity during this time. Then his doctor prescribed Marixino and it literally has been a complete turn around. My period is also now 9 days late and I know I'm not pregnant and I have never missed a period in my life. 2 DOSAGE AND ADMINISTRATION The recommended starting dose of NAMENDA is 5 mg once daily. The less you take the better. Had to go back on Wellbutrin to stay awake. MEMANTINE/N-METHYL-D-ASPARTATE (NMDA) ANTAGONISTS; Moderate Interactions. 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. Memantine has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. Memantine dosing information. One interesting memantine side effect includes higher libido. [157] Therapeutic doses (~10 mg) of memantine induced a mild altered state with cognitive stimulation and altered thought patterns with some parallels to low dose arylcyclohexylamines… Memantine Dosage. He just passed away from surgery complications but after being off it he was NORMAL. Although not all of these side effects may occur, if they do occur they may need medical attention. Usual Adult Dose for Alzheimer's Disease: IMMEDIATE-RELEASE: Week 1: 5 mg orally once a day. About 3 years ago he started having memory problems to the point of not remembering the day of the week or what he had just eaten. She recommended Nameda. After starting again she recovered. The amount of medicine that you take depends on the strength of the medicine. Medicare coverage and pricing details for Memantine. It is pretty bad autism. Memantine will help relieve you of the hyperexcitation of the the nmda circuit that will go bonkers when you quit taking opiates. Then memantine is pulled into the channel to its binding site. It was truly unbelievable. Constipation 3. I'm glad I found this site to know that others have had problems too & it's not just me over thinking. I take therapeutic doses of adderall to treat ADD, and want to manage my tolerance with memantine. He told us to reuse memantine and by the third day the negative side effects we were back. Using it with 100mg Luvox and 450mg Wellbutrin for OCD. My mother's confusion has amplified. However my memory lapses happen every 2 weeks or so and only for a short period. It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to perform daily functions. It helps me in social interactions, I can recognize social cues and skills that I couldn't before! She started it at stage 4. But it isn't a fix-it-all for me. The lowest GoodRx price for the most common version of memantine is around $14.20, 96% off the average retail price of $448.33. Marketing authorisation holder. We are in Scotland so meds are free”, Namenda (memantine) for Alzheimer's Disease: “My sister has Moderate Frontal Lone Alzheimer’s. Patient was clearly getting better in fact even the recent memory was getting better, with the vitamins. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. Over the years many people have toyed with it hoping to use it to abuse recreational drugs and not develop tolerance, this backfired obviously. My mother was on the Exalon patch and my stepmother is on donepazil and memantine. If experienced, these tend to have a Less Severe expression 1. Mine does shortly up to the point I'm about to make as well, so no judgment. Once your dose increases to more than 5 milligrams per day, take this medication twice daily or as dire… Follow your doctor's orders or the directions on the label. Discussion of nootropics and cognitive enhancers. 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